ea0011p370 | Diabetes, metabolism and cardiovascular | ECE2006
Harte AL
, Baker AR
, Hill ML
, Gilardini L
, Girola A
, da Silva NF
, Invitti C
, Kumar S
, McTernan PG
Childhood obesity and its later progression to Type 2 Diabetes (T2DM) are known to be associated with sub-clinical inflammation; although the underlying cause for this is unclear. However, studies suggest that bacterial endotoxin (LPS) derived from commensal bacteria in the human gastrointestinal tract may contribute directly to sub-clinical inflammation. Human adipose tissue expresses toll like receptors that induce an inflammatory cascade in the presence of endotoxin. Hence,...